On July 15, 1975 Soyuz-19 spaceship was lifted aboard Soyuz-U launch vehicle. It was the first international space flight with the docking of Apollo, a US spaceship. The famous Soyuz-Apollo docking was a historical event and a symbol of rapprochement between the two superpowers in the period of détente during the long-lasting Cold War.

Soyuz spaceship was used for the first commercial space flight coordinated by Glavkosmos. In December 1990, a Japanese journalist Toyohiro Akiyama became a member of the crew delivered to MIR space station.

Soyuz-2.1a became the first rocket launched from the new Russian space center Vostochny. The historical launch was conducted on April 28, 2016.